Neuroprotective Effect of Perillyl alcohol in Experimental Sporadic Alzheimer’s disease

Background Alzheimer’s is most common neurodegenerative disorder characterized by memory loss due to accumulation of amyloid- β fibrils. There are different pathologies that count for AD like neuro-inflammation. This study highlights the role oxidative stress and inflammation in progression whereas Perillyl alcohol (POH) shows ant & anti-inflammatory properties. Method 54 Sprague Dawley ICV-STZ (3mg/kg) rats (250-300g, 7-8 weeks) were treated with three doses (25, 50 100mg/kg p.o.) 13 days from 15th 27th day. Weight measured on 1st 28th Behavioral analysis had done using OFT MWM. Result treatment significantly attenuates declined body weight induced dementia rats, showed significant increase crossing number, active time. Dementia unable discriminate familiar novel objects, which improved POH. POH STZ acquisition deficits retention time, increased MDA nitrite levels. attenuated depleted levels GSH, Catalase, SOD comparable standard drug donepezil, decreased AChE cortex hippocampus. Conclusion Study outcomes demonstrate neuroprotective potential against administration streptozotocin behavioural biochemical abnormalities. Biventricular infusion produced impairment learning, memory, cholinergic hypo function elevation hippocampal rats. Rats poor between objects MWM ORT. consequences. Observed beneficial effects include restored functions antioxidant mechanisms.